Maternal diet-induced profiles of liver gene expression and biological functions.

<p>(A) PCA was performed with the top 1,000 most variable genes (based on IQR) of the microarray analysis. (B) The gene expression response (displayed as 2log-ratio of maternal WSD-maternal LFD) of male and female offspring is plotted against each other. (C) By maternal WSD significantly up- or down-regulated genes (<i>p</i>≤0.01) are shown for male and female offspring. (D) Significantly up- or down-regulated genes (<i>p</i>≤0.01) in both sexes were compared and are shown as Venn diagrams. (E) and (F) Ingenuity Pathway Analysis (IPA) was carried out on genes that were significantly differentially expressed upon maternal WSD. The top 25 regulated biological functions in males and females respectively, are displayed. Hatched bars = biological functions that occur in the top 25 of both sexes. Filled bars = biological functions that are specific for one sex. Sys = System.