Ghrelin expressing cells, in the islets of adult-ubiquitous <i>Pax6</i> KO mice, can be differentially identified.

<p>Double immunofluorescence staining of pancreatic cryosections from mice that were injected with tamoxifen at 2 months of age and analysed at 3 weeks post tamoxifen induction. Ghrelin⁺ cells are not detected in the control islets (a). In the ubiquitous <i>Pax6</i> KO islets, ghrelin expression is up regulated and ghrelin⁺ cells may or may not express Pdx1 depending on the fact that they originally come from insulin⁺ or glucagon⁺ cells, respectively (b).