The transcription factor Pax6 is a developmental regulator with a crucial role in development of the eye, brain, and olfactory system. Pax6 is also required for correct development of the endocrine pancreas and specification of hormone producing endocrine cell types. Glucagon-producing cells are almost completely lost in Pax6-null embryos, and insulin-expressing beta and somatostatin-expressing delta cells are reduced. While the developmental role of Pax6 is well-established, investigation of a further role for Pax6 in the maintenance of adult pancreatic function is normally precluded due to neonatal lethality of Pax6-null mice. Here a tamoxifen-inducible ubiquitous Cre transgene was used to inactivate Pax6 at 6 months of age in a condition...
Transcriptional factor paired box 6 (PAX6) is very important for the development of the eyes, centra...
Pax2 is a paired box transcription factor expressed in a spatially and temporally restricted manner ...
Curing diabetes mellitus will require an understanding of the underlying causative genes\ud from dev...
The transcription factor Pax6 is a developmental regulator with a crucial role in development of the...
International audienceThe transcription factor Pax6 is an important regulator of development and cel...
The transcription factor Pax6 is an important regulator of development and cell differentiation in v...
Heterozygous mutations in the human paired box gene PAX6 lead to impaired glucose tolerance. Althoug...
<div><p>The transcription factor <i>Pax6</i> is an important regulator of development and cell diffe...
AbstractPax6 transcription factor is required for islet cell number, morphology, and hormone gene ex...
Pax6 transcription factor is required for islet cell number, morphology, and hormone gene expression...
BACKGROUND: The transcription factor Pax6 functions in the specification and maintenance of the diff...
<p>Double immunofluorescence staining of pancreatic cryosections from mice that were injected with t...
The paired box homeodomain Pax6 is crucial for endocrine cell development and function and plays an ...
<p>(<b>A</b>) Timeline of the experiment. Mice were bred to obtain the various experimental and cont...
The transcription factor paired-box-6 (Pax6) plays a key role in the endocrine differentiation casca...
Transcriptional factor paired box 6 (PAX6) is very important for the development of the eyes, centra...
Pax2 is a paired box transcription factor expressed in a spatially and temporally restricted manner ...
Curing diabetes mellitus will require an understanding of the underlying causative genes\ud from dev...
The transcription factor Pax6 is a developmental regulator with a crucial role in development of the...
International audienceThe transcription factor Pax6 is an important regulator of development and cel...
The transcription factor Pax6 is an important regulator of development and cell differentiation in v...
Heterozygous mutations in the human paired box gene PAX6 lead to impaired glucose tolerance. Althoug...
<div><p>The transcription factor <i>Pax6</i> is an important regulator of development and cell diffe...
AbstractPax6 transcription factor is required for islet cell number, morphology, and hormone gene ex...
Pax6 transcription factor is required for islet cell number, morphology, and hormone gene expression...
BACKGROUND: The transcription factor Pax6 functions in the specification and maintenance of the diff...
<p>Double immunofluorescence staining of pancreatic cryosections from mice that were injected with t...
The paired box homeodomain Pax6 is crucial for endocrine cell development and function and plays an ...
<p>(<b>A</b>) Timeline of the experiment. Mice were bred to obtain the various experimental and cont...
The transcription factor paired-box-6 (Pax6) plays a key role in the endocrine differentiation casca...
Transcriptional factor paired box 6 (PAX6) is very important for the development of the eyes, centra...
Pax2 is a paired box transcription factor expressed in a spatially and temporally restricted manner ...
Curing diabetes mellitus will require an understanding of the underlying causative genes\ud from dev...