Expression of GLP-1 receptor in the islets of beta-cell-specific <i>Pax6</i> KO mice.

<p>Double immunofluorescence staining of pancreatic cryosections from 4 month old mice at 6 weeks after tamoxifen induction. GLP-1 receptor is expressed in both YFP⁺ and YFP^- insulin⁺ cells in the control islets (a-d). In beta-cell-specific <i>Pax6</i> KO islets, GLP-1 receptor expression is lost from the YFP labeled <i>Pax6</i>-deficient cells (arrowheads e-h) but maintained in the YFP^- insulin⁺ cells (arrows e-h).