Double KO of Rap1a and Rap1b leads to lethality of majority of embryos before E10.5.
- Magdalena Chrzanowska-Wodnicka (456845)
- Gilbert C. White II (841261)
- Lawrence A. Quilliam (397209)
- Kevin J. Whitehead (105063)
Publication date
January 2016
DOIAbstract
<p>Stereoscopic images from two (A-C; D-F) of eight analyzed pregnancies resulting from <i>Rap1a</i><sup><i>+/-</i></sup>, <i>Rap1b</i><sup><i>+/-</i></sup> intercrosses. About 80% of <i>Rap1a</i><sup><i>-/-</i></sup><i>; Rap1b</i><sup><i>-/-</i></sup> embryos (A, B, D) fail to develop and pregnancy products are grossly malformed and non-viable. (E) Deletion of both <i>Rap1b</i> and one <i>Rap1a</i> allele leads to severe growth restriction; (C, F) littermate <i>Rap1a</i><sup><i>+/-</i></sup>, <i>Rap1b</i><sup><i>+/+</i></sup> controls. Scale bar: 0.5 mm.</p
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