RIP3 depletion ameliorated lung injury and improved survival rate in LPS-induced ARDS in mice.

<p>(A-B) Pathological changes of lung tissues as determined by H&E staining (200×, n = 5). (C) Body temperature of LPS treated RIP3-WT and RIP3-KO mice (n = 10~16). (D) Survival rate of LPS treated RIP3-WT and RIP3-KO mice (n = 20). RIP3-WT and RIP3-KO mice were both divided into control and LPS groups, respectively. The LPS group mice were instilled with 30 mg/kg LPS, while the control group mice were instilled with PBS. The mice were sacrificed 24 h after LPS instillation. The data are presented as mean±s.e.m; **P<0.01 versus the respective control group; &P<0.05 versus the LPS treated RIP3-WT group.