Profile of genetic interactions and correlations.

<p>(A, B) S scores and correlations for each of the 147’153 gene pairs of the MSP-E-MAP (A) and the MSP/C-E-MAP done on Cerulenin (B). Each of the 147’153 gene pairs is represented by a dot with its x- and y-coordinates corresponding to the S score and profile correlation, respectively. Horizontal and vertical gray lines separate statistically non-significant from significant values (unadjusted P values ≤ 0.005 for S scores and ≤ 0.05 for correlations, respectively). Significant S scores associated with non-significant correlations are in blue, significant correlations associated with non-significant S scores are in red and significant correlations associated with significant S scores are in green. The yellow zones in (A) and (B) together highlight 68 gene pairs with correlations > 0.5 listed in <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1006160#pgen.1006160.s005" target="_blank">S2C Table</a>. Dotted lines indicate significance thresholds (P<0.05) after Bonferroni corrections (<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1006160#pgen.1006160.s005" target="_blank">S2B Table</a>, <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1006160#pgen.1006160.s003" target="_blank">S3 Text</a>, <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1006160#sec013" target="_blank">Materials and Methods</a>). The orange lines indicate the average of significant S scores as a function of the correlation coefficient obtained with a window of 10 values.