Biological correlation of gene expression changes using gene association analysis.

<p>Scatter plots by log₂ fold gene expression changes in LSK, CMP, GMP and MEP cells comparing: top panel, changes due to full trisomy (<i>Ts65Dn/Erg</i>^<i>+/+/+</i> versus <i>Erg</i>^<i>+/+</i>) with those specific for trisomy of <i>Erg</i> (<i>Ts65Dn/Erg</i>^<i>+/+/+</i> vs <i>Ts65Dn/Erg</i>^{<i>+/+/Mld2</i>}); middle panel, expression changes due to full trisomy with those attributable to non<i>-Erg</i> genes in trisomy (<i>Ts65Dn/Erg</i>^{<i>+/+/Mld2</i>} versus E<i>rg</i>^<i>+/+</i>); and lower panel changes attributable to <i>Erg</i> trisomy with those non<i>-Erg</i> genes in trisomy. Green ellipses indicate the strength of biological correlation (ρ_biol) and blue ellipses show technical correlation (ρ_tech) as estimated by GENAS.