Pair-wise comparisons between groups of differential gene expression.

Upper-left Euler diagrams show the amount of overlap between groups regarding DEGs (green and purple circles) and scoDEGs (red and blue circles) for all possible group-wise combinations. Green and red circles relate to row names, while purple and blue circles relate to column names. Size of circles indicates the number of DEGs/scoDEGs, as produced by EdgeR analysis or, in the case of Ackermann and Blanco-Melo, as obtained from the authors. Lower-right Each cell contains information pertaining to the group-wise comparison indicated by the row and column names. Overlap—for each pair-wise comparison between groups the number of scoDEGs that were common to both groups is shown as a percentage of the total number of scoDEGs in the comparison.–log p and r—for each pair-wise comparison, gene expression was compared using the union of scoDEGs for those groups (i.e. single-copy orthologues that were differentially expressed in one or both groups, and that were present in the gene lists for both groups). Pearson correlations were then performed using the log2 fold-changes (log2FC) of those single-copy orthologues to provide–log p and r values. Ackerman provides high r values as this analysis only evaluated expression of 249 inflammation genes (see Table 1). Cells are colored using scales on the right. For upper left and lower right, colored boarders indicate whether comparisons are mouse-human (green), human-human (blue), or mouse-mouse (orange). (PDF)