Influence of overactivation of WNT and/or BMP on attractor canalisation.

<p>Model 1 is the network as shown in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0162052#pone.0162052.g001" target="_blank">Fig 1</a>. Model 2 is the network where the interaction BMP →MEF2C (slow) was replaced by the interaction WNT→MEF2C (slow). In model 3, the interaction BMP →MEF2C (slow) was removed, leaving only RUNX2 to regulate expression of MEF2C mRNA. For each model, the relative size of the attractors basins of RUNX2 and SOX9, and ‘None’ attractors is shown for the overactivation of WNT and/or BMP.