Results of network model simulations.

<p>Gene activity for all genes of the model is presented at distinct network states. A green box indicates activation whereas a red box denotes inactivation of a gene. (A) Summary of the analysis starting simulations from all possible initial states. All runs resulted in one of the three attractors shown. 49% of the simulations resulted in an attractor for the FHF (indicated in purple), 50% in an attractor mimicking the SHF state (indicated in blue) and 1% of the simulations yield an attractor without activation of core cardiac genes. (B) Simulation of time courses from expected initial states of the cardiac gene regulatory network model. Initial state setups differ only in the activation of canonical Wnt signaling at t = 3 (with exogen CanWnt I or without exogen CanWnt II). State transitions match expectations of intermediate state expressions and end in the attractors for FHF and SHF lineages.