Ribosomal genes have significantly larger coefficients for internal than external principal dynamic patterns, but signaling genes exhibit the opposite trend.

<p>The rank values in ascending order of iPDP and ePDP coefficients of ribosomal and signaling genes (cell-cell communication) genes are compared. The y-axis shows the distributions of rank values. Ribosomal genes (white boxes): their average rank values of iPDP coefficients are significantly larger than ePDP ones in both worm (<i>t</i>-test <i>p</i><2.2e-16) and fly (<i>t</i>-test <i>p</i><5.6e-11). Signaling genes (grey boxes): they have significantly larger average rank values of ePDP coefficients than iPDP ones in both worm (<i>t</i>-test p<2.6e-13) and fly (<i>t</i>-test p<8.3e-4).