The GNM-Based Essential Mobility Profiles of the BRAF Dimer Complexes with PLX4720 and Dabrafenib.

<p>Collective dynamics of the BRAF dimers is analyzed using the cumulative contributions of the first five slowest GNM modes. Conformational mobility profiles and structural maps of collective motions are shown for the BRAF dimer complex with PLX4720 (pdb id 3C4C) (A, B) and Dabrafenib (pdb id 4XV2) (C, D). The slow mode shapes are annotated and colored in red (first monomer) and blue (second monomer). Structural maps of collective dynamics are based on fluctuations driven by the slowest five modes. The color gradient from red to blue indicates the increasing structural rigidity and refers to an average value over the backbone atoms in each residue.