Conformational Dynamics Profiles of the BRAF Structures.

<p>Conformational dynamics profiles of the BRAF dimer complexes with PLX4720 (pdb id 3C4C) (A), Dabrafenib (pdb id 4XV2) (B), Vemurafenib (pdb id 3OG7) (C), and PLX7904 (pdb id 4XV1) (D). Conformational mobility profiles of the BRAF dimer complexes are plotted with the reference to the dynamics profile of the BRAF-WT monomeric structure (pdb id 4WO5). The computed B-factors are annotated and colored as follows: the BRAF-WT monomer (in green), the first monomer of the BRAF dimer (in red) and the second monomer of the BRAF dimer (in blue). The positions of the dimer interface residues (D449, W450, K475, W476, H477, D479, R506, R509, H510, F516, Q562, D565, and Y566) are shown on the dynamics profiles filled maroon circles.