AbstractElastic network models are used for investigation of the p53 core domain functional dynamics. Global modes of motion indicate high positive correlations for residue fluctuations across the A-B interface, which are not observed at the B-C interface. Major hinge formation is observed at the A-B interface upon dimerization indicating stability of the A-B dimer. These findings imply A-B as the native dimerization interface, whereas B-C is the crystal interface. The A-B dimer exhibits an opening-closing motion about DNA, supporting the previously suggested clamp-like model of nonspecific DNA binding followed by diffusion. Monomer A has limited positive correlations with DNA, while monomer B exhibits high positive correlations with DNA in...
AbstractThe tetrameric tumor suppressor p53 plays a pivotal role in the control of the cell cycle an...
The p53 tumor suppressor plays a crucial role in maintaining the integrity of the genome by triggeri...
International audienceDNA self-fitting is revealed by the study of intermolecular contacts found in ...
The p53 protein is a transcription factor that acts as the major tumor suppressor in mammals. The co...
The p53 protein is a transcription factor that acts as the major tumor suppressor in mammals. The co...
<p>A, The loop-sheet-helix interaction interface between two p53 molecules revealed by the crystal s...
The p53 protein is frequently mutated in a very large proportion of human tumors, where it seems to ...
The p53 protein is frequently mutated in a very large proportion of human tumors, where it seems to ...
The tumor suppressor p53 is a transcription factor that searches its cognate sites on DNA. During th...
Background: The transient, or permanent, association of proteins to form organized complexes is one ...
Background. The transient, or permanent, association of proteins to form organized complexes is one ...
<div><p>The transactivation domain (TAD) of tumor suppressor p53 can bind with the nuclear coactivat...
<p>(A) Salt bridge formation between monomers A and B. The image illustrates the communication betwe...
The transactivation domain (TAD) of tumor suppressor p53 can bind with the nuclear coactivator bindi...
SummaryRecent studies suggest that p53 binds predominantly to consensus sites composed of two decame...
AbstractThe tetrameric tumor suppressor p53 plays a pivotal role in the control of the cell cycle an...
The p53 tumor suppressor plays a crucial role in maintaining the integrity of the genome by triggeri...
International audienceDNA self-fitting is revealed by the study of intermolecular contacts found in ...
The p53 protein is a transcription factor that acts as the major tumor suppressor in mammals. The co...
The p53 protein is a transcription factor that acts as the major tumor suppressor in mammals. The co...
<p>A, The loop-sheet-helix interaction interface between two p53 molecules revealed by the crystal s...
The p53 protein is frequently mutated in a very large proportion of human tumors, where it seems to ...
The p53 protein is frequently mutated in a very large proportion of human tumors, where it seems to ...
The tumor suppressor p53 is a transcription factor that searches its cognate sites on DNA. During th...
Background: The transient, or permanent, association of proteins to form organized complexes is one ...
Background. The transient, or permanent, association of proteins to form organized complexes is one ...
<div><p>The transactivation domain (TAD) of tumor suppressor p53 can bind with the nuclear coactivat...
<p>(A) Salt bridge formation between monomers A and B. The image illustrates the communication betwe...
The transactivation domain (TAD) of tumor suppressor p53 can bind with the nuclear coactivator bindi...
SummaryRecent studies suggest that p53 binds predominantly to consensus sites composed of two decame...
AbstractThe tetrameric tumor suppressor p53 plays a pivotal role in the control of the cell cycle an...
The p53 tumor suppressor plays a crucial role in maintaining the integrity of the genome by triggeri...
International audienceDNA self-fitting is revealed by the study of intermolecular contacts found in ...