Rescue of <i>Clk</i>^AR ARLI phenotype by <i>Clk</i> expression in the PDF-expressing pacemaker neurons.

<p>(A) Reintroducing <i>Clk</i> expression in the PDF neurons of <i>Clk</i>^AR flies <i>(pdf>Clk;Clk</i>^AR<i>)</i> significantly rescued the premature locomotor decline of the <i>Clk</i>^AR mutation. (B) <i>Clk</i> overexpression in PDF neurons had no effect on SING decline in a wild-type background. Graphs display the means ± SEM from 2 independent experiments.