PDF defines the axonal remodeling of its own neurons.

<p><b>A.</b> Quantitation of total axonal crosses from UAS-PDF rescue experiments. Overexpression of PDF rescues the structural plasticity defects caused by Mmp1 overexpression. “+” in the x axis refers to a single copy of <i>CD8GFP</i>; <i>pdf</i>-GS. Data represents the average (± standard error of the mean) between 3–5 independent experiments and a minimum of 21 flies were analyzed per Genotype/CT. <b>B.</b> PDF downregulation prevents circadian axonal remodeling of sLNv terminals and reduces daytime complexity to nighttime levels. “+” in the x axis refers to a single copy of <i>CD8GFP</i>, <i>Dcr2</i>; <i>pdf</i>-GS. Data represents the average (± standard error of the mean) between 3 independent experiments and a minimum of 25 flies were analyzed per Genotype/CT. In both experiments different letters indicate statistical differences with a p<0.05 (Two-way ANOVA with a Duncan <i>post-hoc</i> test) and all the experimental groups include RU to induce expression.