Response time trends of clusters of co-expressed differential genes by vaccine group.

<p>Co-expressed gene cluster time trends of baseline log₂ fold change in LCPM of DE genes by vaccine group. Header indicates cell type, primary functional classification, and time point. Mean log₂ fold change across cluster genes is drawn in bold. Individual mean gene log₂ fold changes are plotted in lighter colors. Multiscale bootstrapping was used to determine co-expressed gene clusters. <b>(A)</b> Interferon-inducible clusters with increased responses for the AS03-SV group identified in monocytes, B cells and T cells at day 1. <b>(B)</b> Interferon-inducible clusters with similar gene composition but different responses for the AS03-SV group in monocytes and neutrophils at day 1. <b>(C)</b> Additional interferon-inducible cluster modulated by AS03-SV identified in neutrophils at day 3. <b>(D)</b> Cell proliferation-related clusters with increased responses for the AS03-SV group identified in NK cells at day 3. <b>(E)</b> MHC class-II-related cluster with increased responses for the PBS-SV group identified in NK cells at day 28.