Density clustering of expression changes of DE genes in the lungs of influenza infected C57BL/6J mice.

<p>(A) In total, eight different groups of DE genes with similar expression kinetics were identified by cluster analysis as shown in the heat map. (B) The genes for the individual clusters were mapped to significantly associated GO terms of which the most representative terms are depicted. Genes in four clusters were up-regulated and functionally associated with immune responses: Cluster 6 represented a set of 445 DE genes and GO term analysis revealed cytokine production as the most dominating term. Cluster 4 (light green) contained 988 DE genes which were associated with T cell as well as apoptosis-related GO terms. Cluster 2 (orange) contained 37 and cluster 1 (red) 114 genes, respectively, and both were connected to B cell activation. The member genes of each cluster and the results of the GO term analysis are presented in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0041169#pone.0041169.s003" target="_blank">Table S1</a> and <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0041169#pone.0041169.s004" target="_blank">Table S2</a>).