Metal-Free Cascade Approach toward Polysubstituted Indolizines from Chromone-Based Michael Acceptors

An efficient cascade transformation toward indolizine-based molecules has been developed. This process leads to the rapid construction of two C–N bonds and one C–C bond without the need of any metal catalysis. The approach involves easily accessible chromone-based Michael acceptors and propargylamine derivatives as starting materials. This cascade constitutes a novel and very competitive alternative to the well reported strategies using pyridine or pyrrole derivatives for accessing the indolizine ring with substituents at uncommon <i>C</i>-positions