Cyclopentadiene-Phosphine/Palladium-Catalyzed Synthesis of Indolizines from Pyrrole and 1,4-Dibromo-1,3-butadienes

The cyclopentadiene–phosphine ligand (<b>L1</b>) and palladium were found to be an efficient catalyst system to activate the α-C­(sp²)–H bond of pyrrole and indole derivatives. Various alkenyl or aryl dibromides could be used to react with pyrrole and indole derivatives to afford multisubstituted indolizines in high yields