Shift in bioenergetic phenotype in response to metabolic modulators.

<p>The change in relative bioenergetic phenotype of HCASMCs after exposure to 10 mM glucose (in glucose-free medium) (A, n = 8), 5 mM 2-DG (B, n = 8), 1 μM rotenone (C, n = 8), 1 μM antimycin (D, n = 7), 1 μM oligomycin (E, n = 8) and 0.75 μM FCCP (F, n = 8). Shift in bioenergetic phenotype can be detected as relative positional change from basal value (filled circle) after drug application (open square) when ECAR is plotted on the X axis and OCR on the Y axis. Panel G and H summarize percent changes of OCR and ECAR against control level.