The virus neutralization activity of each mAb, depicted as a colored view of each network plot.

<p>Network plots for each of the four gD forms are the same as shown in <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1006430#ppat.1006430.g003" target="_blank">Fig 3</a>. (A) gD1(285t). (B) gD2(285t). (C) gD1(306t). (D) gD2(306t). Neutralization is lensed as a gradient from black to white, with black representing the highest level of activity and white representing no activity. The amount of mAb needed to neutralize 50% of plaques (mg/mL IgG) in a standard plaque reduction assay is listed in <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1006430#ppat.1006430.t001" target="_blank">Table 1</a>. Antibodies that bind both gD1 and gD2 but only neutralize HSV-1 are outlined in orange: 11S, D10-G12, DL15 for gD(285t) and 11S,D10-G12, DL15, AP7, 12S, 11B3AG for gD(306t).