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Data Protection

Neutralization of RSV by MAbs.

Ivy Widjaja (128545)
Alan Rigter (310213)
Shamir Jacobino (655405)
Frank J. M. van Kuppeveld (17308)
Kees Leenhouts (443164)
Concepción Palomo (760052)
Jose A. Melero (300878)
Jeanette H. W. Leusen (192681)
Bert Jan Haijema (444797)
Peter J. M. Rottier (90843)
Cornelis A. M. de Haan (90844)

Publication date

June 2015

DOI

10.1371/journal.pone.0130829.g002

Abstract

<p>The concentration needed of each MAb to achieve 50% neutralization of virus infectivity is graphed. Standard deviations are indicated.</p

Extracted data

Related items

Magnitude and breadth of neutralizing antibodies and parameters of SFV infection Correlations between quantitative measures of neutralization and parameters of infection are presented.

Caroline Lambert (5828999)
Mathilde Couteaudier (5829002)
Julie Gouzil (5829005)
Léa Richard (5829008)
Thomas Montange (835572)
Edouard Betsem (340984)
Réjane Rua (340985)
Joelle Tobaly-Tapiero (5652448)
Dirk Lindemann (223017)
Richard Njouom (313047)
Augustin Mouinga-Ondémé (5661934)
Antoine Gessain (31917)
Florence Buseyne (835573)

October 2018

The neutralization titer against the homologous SFV strain was used; for coinfected individuals we c...

Neutralization of RG viruses by SAP or horse serum.

Emma R. Job (394937)
Barbara Bottazzi (291673)
Brad Gilbertson (394938)
Kathryn M. Edenborough (394939)
Lorena E. Brown (250321)
Alberto Mantovani (287283)
Andrew G. Brooks (330520)
Patrick C. Reading (354655)

March 2013

<p>Dilutions of WT or SAP<sup>R</sup> PR8-PC/73 HA and PR8-Ud/72 HA viruses in TBS were incubated fo...

Neutralization profile of mAbs in different HIV-1 neutralization assays.

Sunita S. Balla-Jhagjhoorsingh (342410)
Betty Willems (165837)
Liesbeth Heyndrickx (342411)
Leo Heyndrickx (114632)
Katleen Vereecken (342412)
Wouter Janssens (342413)
Michael S. Seaman (155998)
Davide Corti (163945)
Antonio Lanzavecchia (75057)
David Davis (190113)
Guido Vanham (114634)

February 2013

<p>% Neutralization obtained with 1∶20 plasma dilution, ≥80% reduction in virus titer is highlighted...

Neutralisation Dose-Response Curves of the MAbs 2G12, 2F5, IgG1b12, and 4E10, Alone and in Combination

Elin Solomonovna Gray (64252)
Tammy Meyers (64253)
Glenda Gray (64254)
David Charles Montefiori (64255)
Lynn Morris (7883)

February 2013

<p>The MAb concentrations in the triple and quadruple combination are represented as the concentrati...

Neutralization of JRFL WT and mutant viruses by different MAbs and CD4-IgG2.

Chitra Upadhyay (817121)
Roya Feyznezhad (4798356)
Weiming Yang (433041)
Hui Zhang (7197)
Susan Zolla-Pazner (156004)
Catarina E. Hioe (210787)

January 2018

<p>Neutralization assays were performed for each of MAb-virus pairs as described in <a href="http://...

Isolated antibody CAP248-2B exhibits low neutralization plateaus, but recapitulates the plasma neutralization breadth.

Constantinos Kurt Wibmer (478449)
Jason Gorman (335528)
Gabriel Ozorowski (711509)
Jinal N. Bhiman (478450)
Daniel J. Sheward (2883902)
Debra H. Elliott (3631078)
Julie Rouelle (3631081)
Ashley Smira (3631075)
M. Gordon Joyce (758829)
Nonkululeko Ndabambi (451424)
Aliaksandr Druz (592100)
Mangai Asokan (3631084)
Dennis R. Burton (106420)
Mark Connors (229169)
Salim S. Abdool Karim (89822)
John R. Mascola (229761)
James E. Robinson (259574)
Andrew B. Ward (409527)
Carolyn Williamson (72867)
Peter D. Kwong (161423)
Lynn Morris (7883)
Penny L. Moore (259519)

January 2017

<p>(A) Bar graph showing percentage neutralization breadth of CAP248 plasma at ID<sub>50</sub> titer...

Neutralization curves of anti-V3 mAbs against representative HIV-1 psVs tested using the TZM.bl target cell line.

Catarina E. Hioe (210787)
Terri Wrin (105334)
Michael S. Seaman (155998)
Xuesong Yu (28930)
Blake Wood (235315)
Steve Self (123890)
Constance Williams (155987)
Miroslaw K. Gorny (156005)
Susan Zolla-Pazner (156004)

February 2013

<p>Seven anti-V3 mAbs were tested against HIV-1 psVs in the TZM.bl experiment. The titration curves ...

The virus neutralization activity of each mAb, depicted as a colored view of each network plot.

Tina M. Cairns (4110190)
Noah T. Ditto (4110187)
Huan Lou (203332)
Benjamin D. Brooks (714084)
Doina Atanasiu (631116)
Roselyn J. Eisenberg (203337)
Gary H. Cohen (203335)

June 2017

<p>Network plots for each of the four gD forms are the same as shown in <a href="http://www.plospath...

Neutralizing antibody or sCD4 induced shedding of gp120 subunit from Env trimers.

Rajesh Ringe (131627)
Lipsa Das (131631)
Ipsita Choudhary (131635)
Deepak Sharma (131639)
Ramesh Paranjape (131642)
Virander Singh Chauhan (131646)
Jayanta Bhattacharya (131652)

October 2012

<p>Infectivity of the virus treated with a ligand was assessed in TZM-bl cells at different time poi...

Neutralizing properties of vaccine-elicited CD4bs-directed MAbs.

Marjon Navis (92808)
Karen Tran (622883)
Shridhar Bale (135639)
Ganesh E. Phad (622884)
Javier Guenaga (150719)
Richard Wilson (308436)
Martina Soldemo (622885)
Krisha McKee (622886)
Christopher Sundling (622887)
John Mascola (622888)
Yuxing Li (263516)
Richard T. Wyatt (150723)
Gunilla B. Karlsson Hedestam (232030)

August 2014

<p>(A) Neutralization activity of four isolated VH1.23-using MAbs from the current study, two previo...

Forward and reverse translational approaches to predict efficacy of neutralizing respiratory syncytial virus (RSV) antibody prophylaxis

Brian M. Maas
Jos Lommerse
Nele Plock
Radha A. Railkar
S.Y. Amy Cheung
Luzelena Caro
Jingxian Chen
Wen Liu
Ying Zhang
Qinlei Huang
Wei Gao
Li Qin
Jie Meng
Han Witjes
Emilie Schindler
Benjamin Guiastrennec
Francesco Bellanti
Daniel S. Spellman
Brad Roadcap
Mariya Kalinova
Juin Fok-Seang
Andrew P. Catchpole
Amy S. Espeseth
S. Aubrey Stoch
Eseng Lai
Kalpit A. Vora
Antonios O. Aliprantis
Jeffrey R. Sachs

November 2021

Background: Neutralizing mAbs can prevent communicable viral diseases. MK-1654 is a respiratory sync...

The neutralization of nine HIV-1 pseudoviruses by mAb 2191 using U87 as target cells.

Catarina E. Hioe (210787)
Terri Wrin (105334)
Michael S. Seaman (155998)
Xuesong Yu (28930)
Blake Wood (235315)
Steve Self (123890)
Constance Williams (155987)
Miroslaw K. Gorny (156005)
Susan Zolla-Pazner (156004)

February 2013

<p>The neutralization curves of anti-V3 mAb 2191 against nine selected HIV-1 pseudoviruses are shown...

Summary of neutralization potency and cross-reactivity of SIV-specific mAbs.

Rosemarie D. Mason (90621)
Hugh C. Welles (3174969)
Cameron Adams (3174966)
Bimal K. Chakrabarti (263511)
Jason Gorman (335528)
Tongqing Zhou (263499)
Richard Nguyen (3174972)
Sijy O’Dell (747190)
Sabrina Lusvarghi (2329267)
Carole A. Bewley (237605)
Hui Li (32376)
George M. Shaw (50361)
Zizhang Sheng (280791)
Lawrence Shapiro (2794138)
Richard Wyatt (2473738)
Peter D. Kwong (161423)
John R. Mascola (229761)
Mario Roederer (5259)

April 2016

<p>SIV mAbs cloned from targeted B cell sorts to isolate CD4bs-, CVNbs-and V1V2-specific B cells. In...

Neutralization curves of anti-V3 mAbs against representative HIV-1 psVs tested using the U87 target cell.

Catarina E. Hioe (210787)
Terri Wrin (105334)
Michael S. Seaman (155998)
Xuesong Yu (28930)
Blake Wood (235315)
Steve Self (123890)
Constance Williams (155987)
Miroslaw K. Gorny (156005)
Susan Zolla-Pazner (156004)

February 2013

<p>Seven anti-V3 mAbs (2191, 2219, 2557, 2558, 3074, 3869, and 447) were tested for neutralization a...

CD4 binding site neutralizing antibody specificity.

Nuria González (4532422)
Krisha McKee (622886)
Rebecca M. Lynch (259552)
Ivelin S. Georgiev (688784)
Laura Jimenez (4984466)
Eulalia Grau (331397)
Eloísa Yuste (331398)
Peter D. Kwong (161423)
John R. Mascola (229761)
José Alcamí (79441)

March 2018

<p>Sera that were ELISA reactive with resurfaced stabilized cores RSC3 and RSC3 G367R, were assayed ...

Magnitude and breadth of neutralizing antibodies and parameters of SFV infection Correlations between quantitative measures of neutralization and parameters of infection are presented.

Caroline Lambert (5828999)
Mathilde Couteaudier (5829002)
Julie Gouzil (5829005)
Léa Richard (5829008)
Thomas Montange (835572)
Edouard Betsem (340984)
Réjane Rua (340985)
Joelle Tobaly-Tapiero (5652448)
Dirk Lindemann (223017)
Richard Njouom (313047)
Augustin Mouinga-Ondémé (5661934)
Antoine Gessain (31917)
Florence Buseyne (835573)

October 2018

The neutralization titer against the homologous SFV strain was used; for coinfected individuals we c...

Neutralization of RG viruses by SAP or horse serum.

Emma R. Job (394937)
Barbara Bottazzi (291673)
Brad Gilbertson (394938)
Kathryn M. Edenborough (394939)
Lorena E. Brown (250321)
Alberto Mantovani (287283)
Andrew G. Brooks (330520)
Patrick C. Reading (354655)

March 2013

<p>Dilutions of WT or SAP<sup>R</sup> PR8-PC/73 HA and PR8-Ud/72 HA viruses in TBS were incubated fo...

Neutralization profile of mAbs in different HIV-1 neutralization assays.

Sunita S. Balla-Jhagjhoorsingh (342410)
Betty Willems (165837)
Liesbeth Heyndrickx (342411)
Leo Heyndrickx (114632)
Katleen Vereecken (342412)
Wouter Janssens (342413)
Michael S. Seaman (155998)
Davide Corti (163945)
Antonio Lanzavecchia (75057)
David Davis (190113)
Guido Vanham (114634)

February 2013

<p>% Neutralization obtained with 1∶20 plasma dilution, ≥80% reduction in virus titer is highlighted...

Neutralisation Dose-Response Curves of the MAbs 2G12, 2F5, IgG1b12, and 4E10, Alone and in Combination

Elin Solomonovna Gray (64252)
Tammy Meyers (64253)
Glenda Gray (64254)
David Charles Montefiori (64255)
Lynn Morris (7883)

February 2013

<p>The MAb concentrations in the triple and quadruple combination are represented as the concentrati...

Neutralization of JRFL WT and mutant viruses by different MAbs and CD4-IgG2.

Chitra Upadhyay (817121)
Roya Feyznezhad (4798356)
Weiming Yang (433041)
Hui Zhang (7197)
Susan Zolla-Pazner (156004)
Catarina E. Hioe (210787)

January 2018

<p>Neutralization assays were performed for each of MAb-virus pairs as described in <a href="http://...

Isolated antibody CAP248-2B exhibits low neutralization plateaus, but recapitulates the plasma neutralization breadth.

Constantinos Kurt Wibmer (478449)
Jason Gorman (335528)
Gabriel Ozorowski (711509)
Jinal N. Bhiman (478450)
Daniel J. Sheward (2883902)
Debra H. Elliott (3631078)
Julie Rouelle (3631081)
Ashley Smira (3631075)
M. Gordon Joyce (758829)
Nonkululeko Ndabambi (451424)
Aliaksandr Druz (592100)
Mangai Asokan (3631084)
Dennis R. Burton (106420)
Mark Connors (229169)
Salim S. Abdool Karim (89822)
John R. Mascola (229761)
James E. Robinson (259574)
Andrew B. Ward (409527)
Carolyn Williamson (72867)
Peter D. Kwong (161423)
Lynn Morris (7883)
Penny L. Moore (259519)

January 2017

<p>(A) Bar graph showing percentage neutralization breadth of CAP248 plasma at ID<sub>50</sub> titer...

Neutralization curves of anti-V3 mAbs against representative HIV-1 psVs tested using the TZM.bl target cell line.

Catarina E. Hioe (210787)
Terri Wrin (105334)
Michael S. Seaman (155998)
Xuesong Yu (28930)
Blake Wood (235315)
Steve Self (123890)
Constance Williams (155987)
Miroslaw K. Gorny (156005)
Susan Zolla-Pazner (156004)

February 2013

<p>Seven anti-V3 mAbs were tested against HIV-1 psVs in the TZM.bl experiment. The titration curves ...

The virus neutralization activity of each mAb, depicted as a colored view of each network plot.

Tina M. Cairns (4110190)
Noah T. Ditto (4110187)
Huan Lou (203332)
Benjamin D. Brooks (714084)
Doina Atanasiu (631116)
Roselyn J. Eisenberg (203337)
Gary H. Cohen (203335)

June 2017

<p>Network plots for each of the four gD forms are the same as shown in <a href="http://www.plospath...

Neutralizing antibody or sCD4 induced shedding of gp120 subunit from Env trimers.

Rajesh Ringe (131627)
Lipsa Das (131631)
Ipsita Choudhary (131635)
Deepak Sharma (131639)
Ramesh Paranjape (131642)
Virander Singh Chauhan (131646)
Jayanta Bhattacharya (131652)

October 2012

<p>Infectivity of the virus treated with a ligand was assessed in TZM-bl cells at different time poi...

Neutralizing properties of vaccine-elicited CD4bs-directed MAbs.

Marjon Navis (92808)
Karen Tran (622883)
Shridhar Bale (135639)
Ganesh E. Phad (622884)
Javier Guenaga (150719)
Richard Wilson (308436)
Martina Soldemo (622885)
Krisha McKee (622886)
Christopher Sundling (622887)
John Mascola (622888)
Yuxing Li (263516)
Richard T. Wyatt (150723)
Gunilla B. Karlsson Hedestam (232030)

August 2014

<p>(A) Neutralization activity of four isolated VH1.23-using MAbs from the current study, two previo...

Forward and reverse translational approaches to predict efficacy of neutralizing respiratory syncytial virus (RSV) antibody prophylaxis

Brian M. Maas
Jos Lommerse
Nele Plock
Radha A. Railkar
S.Y. Amy Cheung
Luzelena Caro
Jingxian Chen
Wen Liu
Ying Zhang
Qinlei Huang
Wei Gao
Li Qin
Jie Meng
Han Witjes
Emilie Schindler
Benjamin Guiastrennec
Francesco Bellanti
Daniel S. Spellman
Brad Roadcap
Mariya Kalinova
Juin Fok-Seang
Andrew P. Catchpole
Amy S. Espeseth
S. Aubrey Stoch
Eseng Lai
Kalpit A. Vora
Antonios O. Aliprantis
Jeffrey R. Sachs

November 2021

Background: Neutralizing mAbs can prevent communicable viral diseases. MK-1654 is a respiratory sync...

The neutralization of nine HIV-1 pseudoviruses by mAb 2191 using U87 as target cells.

Catarina E. Hioe (210787)
Terri Wrin (105334)
Michael S. Seaman (155998)
Xuesong Yu (28930)
Blake Wood (235315)
Steve Self (123890)
Constance Williams (155987)
Miroslaw K. Gorny (156005)
Susan Zolla-Pazner (156004)

February 2013

<p>The neutralization curves of anti-V3 mAb 2191 against nine selected HIV-1 pseudoviruses are shown...

Summary of neutralization potency and cross-reactivity of SIV-specific mAbs.

Rosemarie D. Mason (90621)
Hugh C. Welles (3174969)
Cameron Adams (3174966)
Bimal K. Chakrabarti (263511)
Jason Gorman (335528)
Tongqing Zhou (263499)
Richard Nguyen (3174972)
Sijy O’Dell (747190)
Sabrina Lusvarghi (2329267)
Carole A. Bewley (237605)
Hui Li (32376)
George M. Shaw (50361)
Zizhang Sheng (280791)
Lawrence Shapiro (2794138)
Richard Wyatt (2473738)
Peter D. Kwong (161423)
John R. Mascola (229761)
Mario Roederer (5259)

April 2016

<p>SIV mAbs cloned from targeted B cell sorts to isolate CD4bs-, CVNbs-and V1V2-specific B cells. In...

Neutralization curves of anti-V3 mAbs against representative HIV-1 psVs tested using the U87 target cell.

Catarina E. Hioe (210787)
Terri Wrin (105334)
Michael S. Seaman (155998)
Xuesong Yu (28930)
Blake Wood (235315)
Steve Self (123890)
Constance Williams (155987)
Miroslaw K. Gorny (156005)
Susan Zolla-Pazner (156004)

February 2013

<p>Seven anti-V3 mAbs (2191, 2219, 2557, 2558, 3074, 3869, and 447) were tested for neutralization a...

CD4 binding site neutralizing antibody specificity.

Nuria González (4532422)
Krisha McKee (622886)
Rebecca M. Lynch (259552)
Ivelin S. Georgiev (688784)
Laura Jimenez (4984466)
Eulalia Grau (331397)
Eloísa Yuste (331398)
Peter D. Kwong (161423)
John R. Mascola (229761)
José Alcamí (79441)

March 2018

<p>Sera that were ELISA reactive with resurfaced stabilized cores RSC3 and RSC3 G367R, were assayed ...

Magnitude and breadth of neutralizing antibodies and parameters of SFV infection Correlations between quantitative measures of neutralization and parameters of infection are presented.

Caroline Lambert (5828999)
Mathilde Couteaudier (5829002)
Julie Gouzil (5829005)
Léa Richard (5829008)
Thomas Montange (835572)
Edouard Betsem (340984)
Réjane Rua (340985)
Joelle Tobaly-Tapiero (5652448)
Dirk Lindemann (223017)
Richard Njouom (313047)
Augustin Mouinga-Ondémé (5661934)
Antoine Gessain (31917)
Florence Buseyne (835573)

October 2018

The neutralization titer against the homologous SFV strain was used; for coinfected individuals we c...

Neutralization of RG viruses by SAP or horse serum.

Emma R. Job (394937)
Barbara Bottazzi (291673)
Brad Gilbertson (394938)
Kathryn M. Edenborough (394939)
Lorena E. Brown (250321)
Alberto Mantovani (287283)
Andrew G. Brooks (330520)
Patrick C. Reading (354655)

March 2013

<p>Dilutions of WT or SAP<sup>R</sup> PR8-PC/73 HA and PR8-Ud/72 HA viruses in TBS were incubated fo...

Neutralization profile of mAbs in different HIV-1 neutralization assays.

Sunita S. Balla-Jhagjhoorsingh (342410)
Betty Willems (165837)
Liesbeth Heyndrickx (342411)
Leo Heyndrickx (114632)
Katleen Vereecken (342412)
Wouter Janssens (342413)
Michael S. Seaman (155998)
Davide Corti (163945)
Antonio Lanzavecchia (75057)
David Davis (190113)
Guido Vanham (114634)

February 2013

<p>% Neutralization obtained with 1∶20 plasma dilution, ≥80% reduction in virus titer is highlighted...