Chronic <i>T</i>. <i>muris</i> infection promotes the development of intestinal neoplasia in APC^min/+ mice.

<p><i>T</i>. <i>muris</i> infection at day 18 p.i. and day 42 p.i. in APC^min/+ mice. <b>A</b> Total number of tumours in the intestines of naïve and infected mice at day 18 p.i. <b>B</b> Total number of tumours in intestines of naïve and infected mice at day 42 p.i. <b>C</b> Total tumour area in intestines of naïve and infected mice at d18 and d42 p.i. <b>D</b> Mean tumour area in intestines of naïve and infected mice at d18 and d42 p.i. <b>E</b> Number of tumours in regions of the intestine in naïve and infected mice at day 18 p.i. SA upper, SB mid, SC lower small intestine and LI large intestine. <b>F</b> Number of tumours in regions of the intestine in naïve and infected mice at day 42 p.i. <b>G</b> Size frequency distribution of tumour size between naïve and infected animals at day 42 p.i. <b>H</b> Percentage of proliferating cells in regions of the intestine at day 42 p.i. <b>I</b> Percentage of apoptopic cells in regions of the intestine at day 42 p.i. Black bars denote naïve and grey bars denote infected animals, * significant difference between naïve and infected animals p<0.05, ** p<0.005. APC^min/+ mice from the Paterson Institute, Manchester UK. n = 8–13 per group and repeated twice.