<p>In mice that were allowed to age until moribund, some tumors were adenomas with high-grade dysplasia (A and B), whereas others were intramucosal carcinomas (C-F). The neoplastic cells identified on H&E stained sections (A, C and D) were a mixture of both red and green cells (B, E and F). Panels A and B are shown at the same magnification; size bar = 1mm. Panels C and E are same magnification; size bar = 1mm. Panels D and F are 4x enlargements of the area outlined in C.</p
<p>The number of enlarged Peyer's patches per mouse (size greater than 3 mm, determined by Methylene...
<p>(A) Representative ileal segments obtained from APC<sup>MIN/+</sup> (CCR6WT- APC<sup>MIN/+</sup>)...
<p>Tumors of intestines were observed under a stereoscopic microscope. A and B) The number of small ...
<div><p>A widely accepted paradigm in the field of cancer biology is that solid tumors are uni-ances...
<p>Clonal architecture of intestinal tumors from 20 mosaic mice euthanized at 150 days of age.</p
<p>H&E stained sections of two independent well-differentiated adenocarcinomas (CRC039 and CRC075) s...
Mice lacking Muc2 had an increased ratio of proliferating to apoptotic epithelial cells, resulting i...
Intestinal cancer is a serious and common disease. To understand the mechanisms of its development, ...
Despite great advances in our understanding of tumor initiation and progression, the identity of the...
<p>Hematoxylin and eosin (H&E)-stained tumors from Tg mice at various stages of age: (a) an atypical...
<p>A majority of tumors forming in the mice were fixed and classified by morphology after sectioning...
<p>A. Invasive adenocarcinoma of the antropyloric region (arrows) in a mouse 100 days P.I.. Bar = 12...
Intestinal stem cells are adult, tissue-based stem cells located at the base of the intestinal crypt...
The epithelial layers of the small intestine (SI) and large intestine (LI) are generated via self-re...
The conversion of a normal cell into a metastatic tumor is thought to occur in a stepwise progressio...
<p>The number of enlarged Peyer's patches per mouse (size greater than 3 mm, determined by Methylene...
<p>(A) Representative ileal segments obtained from APC<sup>MIN/+</sup> (CCR6WT- APC<sup>MIN/+</sup>)...
<p>Tumors of intestines were observed under a stereoscopic microscope. A and B) The number of small ...
<div><p>A widely accepted paradigm in the field of cancer biology is that solid tumors are uni-ances...
<p>Clonal architecture of intestinal tumors from 20 mosaic mice euthanized at 150 days of age.</p
<p>H&E stained sections of two independent well-differentiated adenocarcinomas (CRC039 and CRC075) s...
Mice lacking Muc2 had an increased ratio of proliferating to apoptotic epithelial cells, resulting i...
Intestinal cancer is a serious and common disease. To understand the mechanisms of its development, ...
Despite great advances in our understanding of tumor initiation and progression, the identity of the...
<p>Hematoxylin and eosin (H&E)-stained tumors from Tg mice at various stages of age: (a) an atypical...
<p>A majority of tumors forming in the mice were fixed and classified by morphology after sectioning...
<p>A. Invasive adenocarcinoma of the antropyloric region (arrows) in a mouse 100 days P.I.. Bar = 12...
Intestinal stem cells are adult, tissue-based stem cells located at the base of the intestinal crypt...
The epithelial layers of the small intestine (SI) and large intestine (LI) are generated via self-re...
The conversion of a normal cell into a metastatic tumor is thought to occur in a stepwise progressio...
<p>The number of enlarged Peyer's patches per mouse (size greater than 3 mm, determined by Methylene...
<p>(A) Representative ileal segments obtained from APC<sup>MIN/+</sup> (CCR6WT- APC<sup>MIN/+</sup>)...
<p>Tumors of intestines were observed under a stereoscopic microscope. A and B) The number of small ...