<p>Paraffin sections of intestinal adenomas from WT and MCH-KO mice, both of the APCmin background, were stained for (A) TUNEL, a marker of apoptosis; and (B) Ki67, a marker of proliferation. Quantification of differences between the groups (percentage of positive cells per adenoma) is shown in graphs on the right of each picture. *p<0.05.</p
The capacity to model cancer within the mouse has advanced significantly in recent years. Perhaps th...
Sequence analysis of Apc in intestinal tumors from B6/B6-Chr18MSM-F1 ApcMin/+ mice.</p
The availability of murine models with precisely defined genetic lesions has greatly increased our u...
(A, B) Immunofluorescence analysis of small intestinal (A) or colon (B) sections from mice at day 4 ...
<p><b>A</b>) Proliferation was assessed via immunohistochemistry for proliferating cell nuclear anti...
<p>To induce colitis, six week old WT (n = 24) and MCH-KO (n = 32) mice, both of the APCmin backgrou...
Background: Melanin-concentrating hormone (MCH) is an evolutionary conserved hypothalamic neuropepti...
ApcMin/+ and ApcMin/+;Itgb7-/- mice were euthanized between 20–25 weeks and the small bowel was diss...
<p><i>In situ</i> detection of apoptotic cells using TUNEL assay is shown with green fluorescein lab...
We have used mice deficient in a series of genes with either known or potential tumor suppressive ac...
(A) ApcMin/+ and ApcMin/+;Itgb7-/- mice were euthanized between 20–25 weeks, the small bowel was dis...
<p>The colons of AOM-DSS–treated mice were removed after 18 weeks. (A) (upper) Immunohistochemistry ...
<p>(A) A representative western blot showing expression of the wild-type SIRT1 protein in the intest...
Mice lacking Muc2 had an increased ratio of proliferating to apoptotic epithelial cells, resulting i...
<p>(A) Polyp number is shown for the entire small intestine (left panels) and in the duodenum, jejun...
The capacity to model cancer within the mouse has advanced significantly in recent years. Perhaps th...
Sequence analysis of Apc in intestinal tumors from B6/B6-Chr18MSM-F1 ApcMin/+ mice.</p
The availability of murine models with precisely defined genetic lesions has greatly increased our u...
(A, B) Immunofluorescence analysis of small intestinal (A) or colon (B) sections from mice at day 4 ...
<p><b>A</b>) Proliferation was assessed via immunohistochemistry for proliferating cell nuclear anti...
<p>To induce colitis, six week old WT (n = 24) and MCH-KO (n = 32) mice, both of the APCmin backgrou...
Background: Melanin-concentrating hormone (MCH) is an evolutionary conserved hypothalamic neuropepti...
ApcMin/+ and ApcMin/+;Itgb7-/- mice were euthanized between 20–25 weeks and the small bowel was diss...
<p><i>In situ</i> detection of apoptotic cells using TUNEL assay is shown with green fluorescein lab...
We have used mice deficient in a series of genes with either known or potential tumor suppressive ac...
(A) ApcMin/+ and ApcMin/+;Itgb7-/- mice were euthanized between 20–25 weeks, the small bowel was dis...
<p>The colons of AOM-DSS–treated mice were removed after 18 weeks. (A) (upper) Immunohistochemistry ...
<p>(A) A representative western blot showing expression of the wild-type SIRT1 protein in the intest...
Mice lacking Muc2 had an increased ratio of proliferating to apoptotic epithelial cells, resulting i...
<p>(A) Polyp number is shown for the entire small intestine (left panels) and in the duodenum, jejun...
The capacity to model cancer within the mouse has advanced significantly in recent years. Perhaps th...
Sequence analysis of Apc in intestinal tumors from B6/B6-Chr18MSM-F1 ApcMin/+ mice.</p
The availability of murine models with precisely defined genetic lesions has greatly increased our u...