Metabolic profiles of amino acids and derivatives in heatmap format.

<p>The samples are presented along the bottom (Pro^sta, Ama^axe, Pro^log, the numbering represent the biological replicate). For each metabolite, its abundance over the different biological replicates was rescaled between 0 (blue) and 100 (yellow). The corresponding fold changes between conditions are displayed in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0180532#pone.0180532.s003" target="_blank">S3 Table</a>. On the right, the amino acids and derivatives are represented (S: salvage (essential) amino acids, N: <i>de novo</i> (non-essential) amino acids, N+S: amino acids that can be both synthesized <i>de novo</i> and salvaged, but an incomplete pathway for <i>de novo</i> synthesis is described in the Leishcyc and KEGG metabolic databases). The asterisk indicates that another isomer was detected for this metabolite (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0180532#pone.0180532.s002" target="_blank">S2 Table</a> for more details). The branches represent the dendrogram after hierarchical cluster analysis.