Clustering of gene expression and DNA methylation data.

<p>To minimize overlap between cell line names, only the numbers corresponding to the cell lines were displayed. MDS analysis of DNA methylation data shows a distinct cluster of <i>BRAF</i> mutant cell lines; cluster C. Secondary clustering is formed by <i>KRAS</i> mutant samples with low <i>ZNF304</i> expression (cluster B, Figure 2A). MDS analysis of gene expression data showed <i>BRAF</i> mutant samples cluster separately from <i>KRAS</i> mutant and WT samples (2B). The cell lines in cluster B show a 5.9-fold lower <i>ZNF304</i> expression compared to the cell lines in cluster A (2C).