Table of the 110 genes that were significantly associated with PZA-resistance at gene level, which also have mutations significantly associated with PZA-resistance at the mutation level. The association p-value at mutation level was re-calculated excluding the strains harboring mutations strongly related with PZA resistance. These genes were annotated with their molecular function. (DOCX 297Â kb
Non-reference variant frequency histogram, A histogram showing log10(frequency + 1) of non-reference...
The relationship between the total number of non-synonymous SNPs in candidate loci and the MIC value...
Includes bibliographical references (pages 47-56).Pyrazinamide (PZA) is an important first-line drug...
Strains of the study, including their spoligotyping code (15 digits and 43 digits), PZA resistance, ...
Complete results of the analysis by gene, showing for each gene the number of resistant strains with...
Figure S1. The profile of 1110 isolates. (a) The distribution of isolates in three studies. (b) The ...
Variant Position Table, Table detailing variants at all positions with at least one non-synonymous v...
Drug-resistance phenotype frequency table, Drug-resistance phenotype frequency table by lineage. ‘To...
Abstract Background Tuberculosis (TB) is a major global health problem and drug resistance compromis...
Variant Summary Tables, Summary tables of variants called in comparison to the H37rv reference, with...
Study frequency table, Study frequency table, showing numbers and percentage of strains from each st...
Locus Comparison Table, Locus comparison table showing which analyses and in which lineage each loci...
Scree plots for the principal component analyses, Scree plots showing the proportion of variation ac...
Table S3. Ninety three SNPs exhibited significantly different percentages (adjusted p-value<â0.01)...
Sublineage frequency table, Numbers and percentage by lineage assigned to each sublineage. (PPTX 36 ...
Non-reference variant frequency histogram, A histogram showing log10(frequency + 1) of non-reference...
The relationship between the total number of non-synonymous SNPs in candidate loci and the MIC value...
Includes bibliographical references (pages 47-56).Pyrazinamide (PZA) is an important first-line drug...
Strains of the study, including their spoligotyping code (15 digits and 43 digits), PZA resistance, ...
Complete results of the analysis by gene, showing for each gene the number of resistant strains with...
Figure S1. The profile of 1110 isolates. (a) The distribution of isolates in three studies. (b) The ...
Variant Position Table, Table detailing variants at all positions with at least one non-synonymous v...
Drug-resistance phenotype frequency table, Drug-resistance phenotype frequency table by lineage. ‘To...
Abstract Background Tuberculosis (TB) is a major global health problem and drug resistance compromis...
Variant Summary Tables, Summary tables of variants called in comparison to the H37rv reference, with...
Study frequency table, Study frequency table, showing numbers and percentage of strains from each st...
Locus Comparison Table, Locus comparison table showing which analyses and in which lineage each loci...
Scree plots for the principal component analyses, Scree plots showing the proportion of variation ac...
Table S3. Ninety three SNPs exhibited significantly different percentages (adjusted p-value<â0.01)...
Sublineage frequency table, Numbers and percentage by lineage assigned to each sublineage. (PPTX 36 ...
Non-reference variant frequency histogram, A histogram showing log10(frequency + 1) of non-reference...
The relationship between the total number of non-synonymous SNPs in candidate loci and the MIC value...
Includes bibliographical references (pages 47-56).Pyrazinamide (PZA) is an important first-line drug...