Additional file 17: Figure S9. of Guanylate-binding protein-1 is a potential new therapeutic target for triple-negative breast cancer

Proteomic analysis of BRCA tissues by using the RPPA and MS data. (A) Comparison between protein level FC (available from RPPA) and mRNA level FC in TNBC vs Non-TNBC (A) and TNBC vs normal (B) comparisons. RPPA data are limited to only 160 proteins. (C) Volcano plot of the FC versus adjusted p values of proteins from MS dataset [64] in TNBC vs Non-TNBC comparison. Non-DE (or DE but with p-value > 0.05) proteins are shown as gray circles, and DE proteins are shown as blue circles when down-regulated and red circles when up-regulated. Proteins with an FC ≥ +2 and an FC ≤ -2, with an FDR < 0.05, were considered up- and down-regulated, respectively. The numbers outside of circles refer to all proteins that passed the FDR cutoff, while the numbers inside of the circles are DE proteins that passed both the FDR and fold-change cutoffs. (PNG 4403 kb