Role of IFNGR1 signaling in placental inflammation during <i>Pb</i>NK65L infection.

<p>Representative hematoxylin and eosin (H&E)-stained placental sections are shown. Placentas were obtained from uninfected pregnant mice (Uninfected WT, top panels), pregnant WT mice infected with <i>Pb</i>NK65L (infected WT, middle panels), or pregnant IFNGR1-KO mice infected with <i>Pb</i>NK65L (Infected KO, bottom panels) mice on day 6 p.i. (A) Low magnification images of placenta. (B) Higher magnification of labyrinth region (black boxes (i) in A). The scale bars indicate 100 μm. (C) Higher magnification of maternal blood vessel (black boxes (ii) in A). The scale bars indicate 40 μm. (D) Higher magnification of fetal blood vessel (black boxes (iii) in A). The scale bars indicate 40 μm. Regions indicated by white boxes in B–D were enlarged to inset boxes. Arrows indicate <i>Pb</i>NK65L-infected erythrocytes. Experiments using three to five mice were performed in triplicate with similar results, and representative data are shown.