Additional file 8: Figure S8. of Are minor alleles more likely to be risk alleles?

Statistical power analysis for myopia study [18]. The number of cases was 190, and the number of controls was 1064. We assumed that the significance level of the study design was 5.0 × 10− 8, the prevalence was 0.25, the genotype relative risk was 1.6, and the disease model was multiplicative. The graph shows the relationships between disease allele frequency (x-axis) and the statistical power (y-axis). The right top table shows the difference between the statistical power in the minor and major risk allele frequency (p = 0.05 vs. p = 0.95, p = 0.15 vs. p = 0.85, p = 0.25 vs. p = 0.75, p = 0.35 vs. p = 0.65, and p = 0.45 vs. p = 0.55). (TIFF 646 kb