This thesis is devoted to an in-depth analysis of the ability of "Artificial Neural Networks" (ANN) to achieve reliable ground motion predictions. A first important aspect concerns the derivation of "GMPE" (Ground Motion Prediction Equations) with an ANN approach, and the comparison of their performance with those of "classical" GMGEs derived on the basis of empirical regressions with pre-established, more or less complex, functional forms. To perform such a comparison involving the two "betweeen-event" and "within-event" components of the random variability, we adapt the algorithm of the "random effects model" to the neural approach. This approach is tested on various, real and synthetic, datasets: the database compiled from European, Medi...