Biotransformasi 2E-6E-Farnesol Oleh Jamur Endofit Botryosphaeria SP. CA2C-3 Yang Diisolasi Dari Temu Hitam (Curcuma Aeruginosa ROXB.)

The objective of study was to investigate the microbial transformation reaction of 2E-6E-farnesol by the endophyticfungi isolated from temu hitam (Curcuma aeruginosa ROXB. The transformation was carried out in PDB with (2E-6E-farnesol), incubated at room temperature (25-32o C) under shaking condition at 120 rpm for two days produceda major biotransformed product. Structure elucidation based on 1D- and 13C-NMR analysis showed that the biotransformedproduct was 10,11-dihydroxi-2E-6E-farnesol. It It was verified that biotransformation reaction of 2E-6E-farnesol into 10,11-dihydroxi-2E-6E-farnesol through an intermediate 10,11-epoxi-2E-6E-farnesol