Exploiting the enantioselectivity of Baeyer-Villiger monooxygenases via boron oxidation
- Andrade, Leandro H.,
- Fraaije, Marco W.,
- Reis, Joel S.,
- Dudek, Hanna,
- Brondani, Patrícia B.,
Publication date
January 2012
DOI ISSN
0957-4166 Citation count (estimate)
10Abstract
The enantioselective carbon–boron bond oxidation of several chiral boron-containing compounds by Baeyer-Villiger monooxygenases was evaluated. PAMO and M446G PAMO conveniently oxidized 1-phenylethyl boronate into the corresponding 1-(phenyl)ethanol (ee = 82–91%). Cyclopropyl boronic esters were also oxidized but with no enantioselectivity. β-Boryl carboxylic esters were not oxidized by any BVMOs.
Add to ORKG