Exploiting the enantioselectivity of Baeyer-Villiger monooxygenases via boron oxidation
- Brondani, Patricia B.
- Dudek, Hanna
- Reis, Joel S.
- Fraaije, Marco W.
- Andrade, Leandro H.
Publication date
May 2012
DOIAbstract
The enantioselective carbon-boron bond oxidation of several chiral boron-containing compounds by Baeyer-Villiger monooxygenases was evaluated. PAMO and M446G PAMO conveniently oxidized 1-phenylethyl boronate into the corresponding 1-(phenyl)ethanol (ee = 82-91%). Cyclopropyl boronic esters were also oxidized but with no enantioselectivity. beta-Boryl carboxylic esters were not oxidized by any BVMOs. (C) 2012 Elsevier Ltd. All rights reserved
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