Studies on the Metabolism of Bile Pigment in Vivo Part 2 Studies on the Reduction of Biliverdin to Bilirubin with the Use of the Liver Tissue in an Aerobic Condition

The prosperity and decay of bilirubin and biliverdin were observed on the action of the liver tissue in healthy guinea pig and the guinea pig with administration of carbon tetrachloride and thrombosis of the reticuloendothelial system to the untreated rabbit bile or treated rabbit bile by adding of various carbohydrates. The results are as follows. 1. Bilirubin is partly oxidized to biliverdin on the shaking of rabbit bile in the thermostat at 38℃. It's biliverdin and biliverdin in rabbit bile are more analysed on the same treatment. 2. Biliverdin in rabbit bile is partly reduced to bilirubin on the action of the liver tissue in healthy guinea pig to rabbit bile. 3. The tendency which biliverdin is partly reduced to bilirubin is observed on the action of the liver tissue in the guinea pig with administration of carbon tetrachloride to rabbit bile, but it's action is not so strong. 4. The tendency which biliverdin increases rather than helps the progress reducing biliverdin to bilirubin is observed on the action of the liver tissue in the guinea pig with thrombosis of the reticuloendothelial system to rabbit bile. 5. Since the above results, the reticuloendothelial system seems to mainly participate in the reduction of biliverdin to bilirubin on the use of the liver tissue in guinea pig