Oncosuppressive properties and a low pathogenicity in adult animals make the two rodent parvoviruses MVMp and H1 promising vectors for cancer gene therapy. Recombinant vectors were developed from genomes of these viruses in which a part of the capsid-protein-coding sequence was replaced by a transgene. These recombinant viruses can replicate their genome and express their transgene, but they are unable to produce progeny viruses. Such vectors are produced by cotransfection of the recombinant virus genome and a helper plasmid which provides the capsid proteins. During this procedure, RCVs (Replication Competent Viruses) can be generated, probably by homologous recombination. As a consequence, RCVs can express their capsid proteins and produc...
Die aktive Demethylierung der DNA, die zu einer Reaktivierung stillgelegter Gene führen kann, beschä...
The evolutionary success of insects is believed to be at least partially facilitated by symbioses be...
The severe acute respiratory syndrome (SARS) was first observed in the Chinese province Guangdong in...
Oncosuppressive properties and a low pathogenicity in adult animals make the two rodent parvoviruses...
Herpesviruses are small pathogenic agents that cause diseases in animals and humans and persist life...
Abbreviations vii Zusammenfassung xi Summary xv 1 Introduction 1 1.1 The global AIDS epidemic and it...
1\. EINLEITUNG 8 1.1. Parvovirus B19 (B19V) 8 1.1.1. Taxonomie 8 1.1.2. Morphologie und Genomstruktu...
Titelblatt, Inhaltsverzeichnis, Danksagung, Lebenslauf, Selbstständigkeitserklärung 1\. Einleitung...
SIVsmmPBj-derived lentiviral vectors are capable of efficient primary human monocyte transduction, a...
Abbildungsverzeichnis VI Tabellenverzeichnis VII 1 Einleitung 1 1.1 Das adaptive Immunsystem 1 1.1.1...
For the first time the complete BHV-1 Schönböken genome was cloned as an infectious bacterial artifi...
Das Immunsystem der Vertebraten musste sich während der Evolution stetig verbessern, um sich ebenfal...
Vorkommen und Verteilungsmuster von Angiotensin I-converting enzyme (ACE, Kininase II, CD143), das d...
In the post-genomic era, highly specific nucleases became important tools for directed gene targetin...
Table of Contents General Introduction 1 1.1 Infection and Immunity 1 1.1.1 Infection 1 1.1.2 Virule...
Die aktive Demethylierung der DNA, die zu einer Reaktivierung stillgelegter Gene führen kann, beschä...
The evolutionary success of insects is believed to be at least partially facilitated by symbioses be...
The severe acute respiratory syndrome (SARS) was first observed in the Chinese province Guangdong in...
Oncosuppressive properties and a low pathogenicity in adult animals make the two rodent parvoviruses...
Herpesviruses are small pathogenic agents that cause diseases in animals and humans and persist life...
Abbreviations vii Zusammenfassung xi Summary xv 1 Introduction 1 1.1 The global AIDS epidemic and it...
1\. EINLEITUNG 8 1.1. Parvovirus B19 (B19V) 8 1.1.1. Taxonomie 8 1.1.2. Morphologie und Genomstruktu...
Titelblatt, Inhaltsverzeichnis, Danksagung, Lebenslauf, Selbstständigkeitserklärung 1\. Einleitung...
SIVsmmPBj-derived lentiviral vectors are capable of efficient primary human monocyte transduction, a...
Abbildungsverzeichnis VI Tabellenverzeichnis VII 1 Einleitung 1 1.1 Das adaptive Immunsystem 1 1.1.1...
For the first time the complete BHV-1 Schönböken genome was cloned as an infectious bacterial artifi...
Das Immunsystem der Vertebraten musste sich während der Evolution stetig verbessern, um sich ebenfal...
Vorkommen und Verteilungsmuster von Angiotensin I-converting enzyme (ACE, Kininase II, CD143), das d...
In the post-genomic era, highly specific nucleases became important tools for directed gene targetin...
Table of Contents General Introduction 1 1.1 Infection and Immunity 1 1.1.1 Infection 1 1.1.2 Virule...
Die aktive Demethylierung der DNA, die zu einer Reaktivierung stillgelegter Gene führen kann, beschä...
The evolutionary success of insects is believed to be at least partially facilitated by symbioses be...
The severe acute respiratory syndrome (SARS) was first observed in the Chinese province Guangdong in...