Relation of plasma renin to sodium balance and arterial pressure in experimental renal hypertension. Circulation

stricted the renal arteries in dogs and pro-duced chronic arterial hypertension. Numer-ous attempts have been made to elucidate the mechanisms responsible for this sustained elevation of arterial pressure and many workers have suggested that there is in-creased activity of the renin-angiotensin sys-tem. In recent years, several studies2"0 have indicated that circulating renin and angio-tensin 11 are elevated only in malignant * ex-perimental renal hypertension and during the first few days in dogs developing chronic* renal hypertension. The possibility remains, however, that there is a small undetectable elevation in plasma renin and angiotensin n which is important in the pathogenesis of chronic renal hypertension