Sequential renal hemodynamics in experimen- tal benign and mabgnant hypertension. Hypertension 3, Suppl. I

SUMMARY To examine the sequential renal hemodynamic changes in experimental renovascular hyper-tension, the uninephrectomized dog was studied immediately after renal artery constriction, throughout chronic benign hypertension, and during malignant hypertension. Intrarenal resistance fell immediately after renal artery constriction, but rose above control within hours. Intrarenal infusion of teprotide resulted in vasodilatation during the first 3 days but failed to do so during the chronic phase of benign hypertension. Dur-ing the transition from benign to malignant hypertension, angiotensin II-dependent renal vasoconstriction developed associated with natriuresis, plasma volume contraction and a vicious cycle of hyperreninemia and severe vascular damage. (Hypertension 3 (supp I): I-63-I-68, 1981) KEY WORDS • renal hemodynamics renin-angiotensin system benign hypertension • malignant hypertension G OLDBLATT et al.1 first produced experi-mental benign hypertension by moderateconstriction of trie renal artery in the uninephrectomized dog, or of both renal arteries in the intact dog. Many investigators have confirmed his observations and have also reported that hyper