Infiltration in Breast Cancer

Leukocyte migration inhibition (LMI) in patients with breast cancer was examined by using 3 M-KCI tissue extracts of breast tumors. Tumor extracts were obtained from 12 breast carcinomas of various histological types. In 20 of 65 (30.8%) leukocyte preparations from 25 patients with breast cancer migration was inhibited by breast cancer tissue extracts. In 26 leukocyte pre-parations from eight healthy persons and 22 preparations from eight patients with benign diseases of the breast migration was not inhibited by the breast cancer extracts. In only two of 47 (4.3%) leukocyte preparations from 12 pa-tients with other cancers migration was inhibited by the extracts. The occurrence of LMI was the highest in leukocytes from the patients with breast cancer showing marked nuclear pleomorphism (10/19, 52.6%) or show-ing marked mononuclear cell infiltration (6/12, 50.0%). These results suggest that 3 M-K.C1 tissue extracts of breast cancer may con-tain tumor-associated antigens in solubilized form and that there may be a cor-relation between LMI and nuclear pleomorphism of cancer cells of the leuko-cyte donor as well as mononuclear cell infiltration in the tumor of the leukocyte donor