DOIAbstract
Summary.-Leucocyte migration inhibition by autologous breast tumour cell fractions was mediated by a soluble factor synthesized and released by mononuclear leucocytes and active against migrating granulocytes. This mechanism is similar to that previously described in respect to cell-mediated sensitivity to microbial antigens. Alternative mechanisms involving directly reactive granulocytes or cytophilic antibodies were rarely operative in the migration tests. THE leucocyte migration test (LMT) of S0borg and Bendixen (1967) has been successfully employed in studies of tu-mour-directedimmuneresponses inpatients with breast cancer (Andersen et al., 1970; Cochran et al., 1974; Jones and Turnbull
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