Editorials: CEll CyClE FEaturEs www.landesbioscience.com Cell Cycle 3127

The process by which organisms evolved elaborate signaling networks is a fascinating mystery in the fields of evolu-tionary and cellular biology. Emergence, diversity, and evolution of signaling net-works are being rapidly understood with improved knowledge of various genomes. However, continued progress must not solely depend on analyses of the primary gene and protein sequences, rather, we must incorporate analyses of the evolution of the physical, dynamic, and biochemi-cal properties of the encoded signaling elements. For example, compare the Gα subunits of the animal and plant het