Add to ORKGMeiosis is a special cell division program that reduces the diploid chromosome set to a haploid set for sexual reproduction. Reductional segregation of homologous chromosomes is helped by physical link-ages (crossovers) provided by recombina-tion. A long-standing problem in biology has been to understand how meiotic recom-bination is controlled, since its initiation by DNA double-strand breaks (DSBs) is a programmed damage that could be lethal and is highly organized temporally and spatially throughout the genome. Much of our current knowledge comes from work in fungi, notably the budding yeas
nuclear architecture and tran-scription are related has been a “black box ” in cell biology. Whether...
The cell division cycle is the sequence of events whereby a cell duplicates its components and divid...
Understanding the regulatory mecha-nisms that produce quantitatively precise and spatiotemporally re...
DNA double-strand breaks (DSBs) can be lethal to a cell. However, most sexually reproducing organism...
To maintain genome stability during fluctuating environmental conditions, cells have adapted mechani...
are dangerous lesions that occur when both strands of the DNA double helix are broken. Repair of DSB...
Genome-wide chromatin interaction studies demonstrate that chromosomes are organized in distinct dom...
Sexual reproduction ensures the con-tinued propagation of almost all eukary-otic species. Two morpho...
Human cells must faithfully dupli-cate billions of base pairs of DNA every cell division cycle. Insu...
have evolved several mechanisms to deal with the constant challenge of DNA replication fork arrest d...
Complete DNA replication prior to cell division is essential, so that each daugh-ter cell receives a...
The centromere is a unique region of the chromosome that defines the site of kinetochore assembly an...
The proper regulation and spatial orga-nization of heterochromatin is crucial for a broad range of c...
Ensuring that mutations are not propa-gated within stem cell populations is key to proper developmen...
Senescence is an irreversible loss of cel-lular proliferative capacity and, together with apoptosis,...
nuclear architecture and tran-scription are related has been a “black box ” in cell biology. Whether...
The cell division cycle is the sequence of events whereby a cell duplicates its components and divid...
Understanding the regulatory mecha-nisms that produce quantitatively precise and spatiotemporally re...
DNA double-strand breaks (DSBs) can be lethal to a cell. However, most sexually reproducing organism...
To maintain genome stability during fluctuating environmental conditions, cells have adapted mechani...
are dangerous lesions that occur when both strands of the DNA double helix are broken. Repair of DSB...
Genome-wide chromatin interaction studies demonstrate that chromosomes are organized in distinct dom...
Sexual reproduction ensures the con-tinued propagation of almost all eukary-otic species. Two morpho...
Human cells must faithfully dupli-cate billions of base pairs of DNA every cell division cycle. Insu...
have evolved several mechanisms to deal with the constant challenge of DNA replication fork arrest d...
Complete DNA replication prior to cell division is essential, so that each daugh-ter cell receives a...
The centromere is a unique region of the chromosome that defines the site of kinetochore assembly an...
The proper regulation and spatial orga-nization of heterochromatin is crucial for a broad range of c...
Ensuring that mutations are not propa-gated within stem cell populations is key to proper developmen...
Senescence is an irreversible loss of cel-lular proliferative capacity and, together with apoptosis,...
nuclear architecture and tran-scription are related has been a “black box ” in cell biology. Whether...
The cell division cycle is the sequence of events whereby a cell duplicates its components and divid...
Understanding the regulatory mecha-nisms that produce quantitatively precise and spatiotemporally re...