TEMPORAL EFFECTS OF CARBOSULFAN ON TESTICULAR BIOCHEMICAL PARAMETERS AND ENZYME ACTIVITIES IN ALBINO MICE

Carbosulfan a N- methyl insecticide was administered orally with an effective dose of 48 mg/kg body weight per day to mice for 5, 10 20 and 30 days to examine the temporal effects. Mice were sacrificed on 31st day. Treatment with Carbosulfan for 20 and 30 days caused significant decrease in protein, glycogen and sialic acid where as cholesterol increased significantly in testis. The activities of succinic dehydrogenase (SDH), acid phosphatase (ACP), were decreased significantly, whereas lactate dehydrogenase (LDH) and alkaline phosphatase (AKP) activities were increased significantly in testis, 3β hydroxysteroid dehydrogenase (3βHSD) decreased significantly in the mice treated with Carbosulfan for 20 and 30 days. These biochemical changes seem to be the genotoxic action leading to metabolic or hormonal imbalance in any of the stage in the hypothalamo-hypophysial-testicular axis in mice