diagnóstico de trombose e investigados no Hospital Israelita Albert Einstein, São Paulo, Brasil

Objective: To evaluate the prevalence of genetic polymorphism in coagulation factors in thromboembolic disease in patients with clinical suspicion of thrombosis. Methods: A retrospective case collection was performed searching all patients with clinical suspicion of thrombosis who were submitted to coagulation factor analysis at the Hospital Israelita Albert Einstein from November 2003 to April 2004. We included 260 patients, 118 male and 142 female, mean age of 46 years. Prothrombin mutation and Leiden V factor were evaluated with multiplex PCR. Protein C, S and lupus anticoagulant were studied in coagulation assays. Antithrombin III was studied by chromogenic assay. Anticardiolipin was evaluated through an immunoenzymatic method and homocysteine by an immunometric method. Results: Factor V Leiden was found in 22 cases (8.3 %), one homozygote and 21 heterozygotes. Prothrombi