The role of the naturally occurring polyamides distamycin and netropsin as antibacterial agents is described. Also, the importance of the modifications to the lipophilic and hydrophobic moieties is discussed. It has also been shown that these DNA minor groove binding compds. can be used to treat other diseases such as sleeping sickness when the right modifications have been employed. Examples of the synthetic strategy of these polypyrroles are also highlighted in this review
A review with 39 refs. Analogs of naturally occurring antitumor agents, such us distamycin A, which...
It goes without saying now that there is a severe risk to health world wide because of the continued...
The synthesis and properties of 80 short minor groove binders related to distamycin and the thiazotr...
The role of the naturally occurring polyamides distamycin and netropsin as antibacterial agents is d...
The synthesis and biological activity of a variety of analogues to the naturally occurring anti-bact...
Several classes of compounds, including heterocyclic polyamides, aryl benzimidazoles, pyrrolobenzodi...
The polyamide minor groove binders (MGBs), distamycin and netropsin, have been known for many years ...
Natural products that bind to DNA in the minor groove are valuable templates for drug design. Exampl...
Minor groove binders are small molecules that form strong complexes with the minor groove of DNA. Th...
The development of small-molecules which target nucleic acids, more specifically the minor groove of...
The search for novel anti-infective and anticancer drugs ranges over many types of compound. Followi...
The natural product distamycin contains three N-methylpyrrole amino acids and binds in the minor gro...
DNA minor groove binders constitute an important class of derivatives in anticancer therapy. Some of...
Analogues of distamycin which retain the parent ligand's ability to bind in the DNA minor groove wit...
The synthesis and properties of 80 short minor groove binders related to distamycin and the thiazotr...
A review with 39 refs. Analogs of naturally occurring antitumor agents, such us distamycin A, which...
It goes without saying now that there is a severe risk to health world wide because of the continued...
The synthesis and properties of 80 short minor groove binders related to distamycin and the thiazotr...
The role of the naturally occurring polyamides distamycin and netropsin as antibacterial agents is d...
The synthesis and biological activity of a variety of analogues to the naturally occurring anti-bact...
Several classes of compounds, including heterocyclic polyamides, aryl benzimidazoles, pyrrolobenzodi...
The polyamide minor groove binders (MGBs), distamycin and netropsin, have been known for many years ...
Natural products that bind to DNA in the minor groove are valuable templates for drug design. Exampl...
Minor groove binders are small molecules that form strong complexes with the minor groove of DNA. Th...
The development of small-molecules which target nucleic acids, more specifically the minor groove of...
The search for novel anti-infective and anticancer drugs ranges over many types of compound. Followi...
The natural product distamycin contains three N-methylpyrrole amino acids and binds in the minor gro...
DNA minor groove binders constitute an important class of derivatives in anticancer therapy. Some of...
Analogues of distamycin which retain the parent ligand's ability to bind in the DNA minor groove wit...
The synthesis and properties of 80 short minor groove binders related to distamycin and the thiazotr...
A review with 39 refs. Analogs of naturally occurring antitumor agents, such us distamycin A, which...
It goes without saying now that there is a severe risk to health world wide because of the continued...
The synthesis and properties of 80 short minor groove binders related to distamycin and the thiazotr...
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