Specific plasminogen-binding sites of fibrin molecule are located in Аα148-160 regions of C-terminal domains. Plasminogen interaction with these sites initiates the activation process of proenzyme and subsequent fibrin lysis. In this study we investigated the binding of plasminogen fragments K 1-3 and K 5 with fibrin fragment DD and their effect on Glu-plasminogen interaction with DD. It was shown that the level of Glu-plasminogen binding to fibrin fragment DD is decreased by 50-60% in the presence of K 1-3 and K 5. Fragments K 1-3 and K 5 have high affinity to fibrin fragment DD (Kd is 0.02 for K 1-3 and 0.054 μМ for K 5). K 5 interaction is independent and K 1-3 is partly dependent on C-terminal lysine residues. K 1-3 interacts with compl...
AbstractExperiments involving affinity chromatography on immobilized plasminogen columns and the con...
Plasminogen/plasmin system is involved in such important processes as thrombosis, inflammation and c...
Plasminogen is the proenzyme precursor of the primary fibrinolytic protease plasmin. Circulating pla...
AbstractAffinity chromatography of plasminogen and its proteolytic fragments on immobilized fibrinog...
Fibrin clot lysis by plasminogen/plasmin system results in fibrin degradation products formation wit...
AbstractAffinity chromatography of plasminogen and its proteolytic fragments on immobilized fibrinog...
A well characterized model of an intact and a degraded surface of fibrin that represents the states ...
Over-activation of the fibrinolytic system may result in proteolytic destruction of fibrinogen. Howe...
To describe the role of the lysyl binding site in the interaction of tissue-type plasminogen activat...
Fibrin clot lysis by plasminogen/plasmin system results in fibrin degradation products formation wit...
150 p.Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1984.Fibrinolysis refers to the pr...
Fibrin clot lysis by plasminogen/plasmin system results in fibrin degradation products formation wit...
Fibrin clot lysis by plasminogen/plasmin system results in fibrin degradation products formation wit...
150 p.Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1984.Fibrinolysis refers to the pr...
Fibrin clot lysis by plasminogen/plasmin system results in fibrin degradation products formation wit...
AbstractExperiments involving affinity chromatography on immobilized plasminogen columns and the con...
Plasminogen/plasmin system is involved in such important processes as thrombosis, inflammation and c...
Plasminogen is the proenzyme precursor of the primary fibrinolytic protease plasmin. Circulating pla...
AbstractAffinity chromatography of plasminogen and its proteolytic fragments on immobilized fibrinog...
Fibrin clot lysis by plasminogen/plasmin system results in fibrin degradation products formation wit...
AbstractAffinity chromatography of plasminogen and its proteolytic fragments on immobilized fibrinog...
A well characterized model of an intact and a degraded surface of fibrin that represents the states ...
Over-activation of the fibrinolytic system may result in proteolytic destruction of fibrinogen. Howe...
To describe the role of the lysyl binding site in the interaction of tissue-type plasminogen activat...
Fibrin clot lysis by plasminogen/plasmin system results in fibrin degradation products formation wit...
150 p.Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1984.Fibrinolysis refers to the pr...
Fibrin clot lysis by plasminogen/plasmin system results in fibrin degradation products formation wit...
Fibrin clot lysis by plasminogen/plasmin system results in fibrin degradation products formation wit...
150 p.Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1984.Fibrinolysis refers to the pr...
Fibrin clot lysis by plasminogen/plasmin system results in fibrin degradation products formation wit...
AbstractExperiments involving affinity chromatography on immobilized plasminogen columns and the con...
Plasminogen/plasmin system is involved in such important processes as thrombosis, inflammation and c...
Plasminogen is the proenzyme precursor of the primary fibrinolytic protease plasmin. Circulating pla...