C-terminal lysine residues of fibrinogen fragments essential for binding to plasminogen

AbstractExperiments involving affinity chromatography on immobilized plasminogen columns and the concomitant use of plasmin and carboxypeptidase B indicate that the COOH-terminal lysine residues formed by plasmincatalyzed cleavage of fibrinogen are essential for the high-affinity binding of the resulting cleavage products to plasminogen.C-terminal lysine residueFibrinogenPlasminogenLysine binding siteFibrinogen fragment DFibrinogen fragment